| WOUND STAGES |
COLLAGEN'S ROLE |
| INJURY |
|
1. HEMOSTASIS
Blood platelets stick to exposed collagen
and to each other, plugging broken blood vessels. |
Helps in the
formation of a plug to stop the bleeding. |
2. REACTION
Phase characterized by inflammation and
decreased blood flow to the wound. White blood cells move in to fight infection. |
Absorbs fluid
to clean wound and remove bacteria. Provides environment for macrophages. |
3. REGENERATION
Body begins repairing itself by generating
granulation tissue. The epidermis is restored. The wound closes. |
Attracts cells
to wound site. Provides optimal environment for cell growth and vascularization |
| a. Granulation.
Cells migrate into wound, forming a matrix to fill the tissue void (RED). |
Attracts cells
to wound site and promotes granulation. |
| b. Epithelialization.
Once a healthy granulation bed is established, a 2- to 3- layer epidermis
forms over the surface. |
Provides bridge
for epithelial cells. Integral in angiogenisis. |
| c. Contracture.
Tissue can now withstand normal stresses (PINK). |
Accelerates tissue
reconstruction. Reduces scarring. |
4. REMODELING
Final stage of wound healing. Most of
original tissue strength is regained. |
Increases and
consolidates fibers to strengthen the integrity of the tissue. |
|
HEALED
|
WOUND |
